Runx2-I isoform contributes to fetal bone formation even in the absence of specific N-terminal amino acids.

The Runt-related transcription factor 2 (Runx2) gene encodes the transcription factor Runx2, which is the master regulator of osteoblast development; insufficiency of this protein causes disorders of bone development such as cleidocranial dysplasia. Runx2 has two isoforms, Runx2-II and Runx2-I, and...

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Bibliographic Details
Main Authors: Hideaki Okura, Shintaro Sato, Sari Kishikawa, Satoshi Kaneto, Tomoki Nakashima, Nobuaki Yoshida, Hiroshi Takayanagi, Hiroshi Kiyono
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4171521?pdf=render