The design of fluoroquinolone-based cholinesterase inhibitors: Synthesis, biological evaluation and in silico docking studies

The design of fluoroquinolone-based cholinesterase inhibitors: Synthesis, biological evaluation and in silico docking studies

An enhanced acetylcholinesterase (AChE) activity is a hallmark in early stages of Alzheimer's ailment that results in decreased acetylcholine (ACh) levels, which in turn leads to cholinergic dysfunction and neurodegeneration. Consequently, inhibition of both AChE and butyrylcholinesterase (BChE...

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Bibliographic Details
Main Authors: Muhammad Mansha, Muhammad Taha, El Hassane Anouar, Nisar Ullah
Format: Article
Language:English
Published: Elsevier 2021-07-01
Series:Arabian Journal of Chemistry
Subjects:
Fluoroquinolone derivatives
Acetylcholinesterase
Butyrylcholinesterase
Molecular docking
SAR
Online Access:http://www.sciencedirect.com/science/article/pii/S1878535221002264

Internet

http://www.sciencedirect.com/science/article/pii/S1878535221002264

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