Focal Adhesion Kinase (FAK) Over-Expression and Prognostic Implication in Pediatric Hepatocellular Carcinoma

Focal Adhesion Kinase (FAK) Over-Expression and Prognostic Implication in Pediatric Hepatocellular Carcinoma

Focal adhesion kinase (FAK) is over-expressed and is correlated with aggressiveness in adult hepatocellular carcinoma (HCC). Inhibition of FAK decreases HCC invasiveness by down-regulating Enhancer of Zeste homolog 2 (EZH2), an epigenetic controller, that acts in transcriptional repression of a larg...

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Bibliographic Details
Main Authors: Paola Francalanci, Isabella Giovannoni, Cristiano De Stefanis, Ilaria Romito, Chiara Grimaldi, Aurora Castellano, Valentina D’Oria, Rita Alaggio, Anna Alisi
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:International Journal of Molecular Sciences
Subjects:
pediatric hepatocellular carcinoma
focal adhesion kinase
enhancer of Zeste homolog 2
β-Catenin
cirrhosis
normal liver
Online Access:https://www.mdpi.com/1422-0067/21/16/5795

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https://www.mdpi.com/1422-0067/21/16/5795

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