A Model for NAD(P)H:Quinoneoxidoreductase 1 (NQO1) Targeted Individualized Cancer Chemotherapy

A Model for NAD(P)H:Quinoneoxidoreductase 1 (NQO1) Targeted Individualized Cancer Chemotherapy

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NQO1 (NAD(P)H:quinoneoxidoreductase 1) is a reductive enzyme that is an important activator of bioreductive antitumor agents. NQO1 activity varies in individual tumors but is generally higher in tumor cells than in normal cells. NQO1 has been used as a target for tumor specific drug development. We...

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Bibliographic Details
Main Authors: Asher Begleiter, Nadia El-Gabalawy, Laurie Lange, Marsha K. Leith, Lynn J. Guziec, Frank S. Guziec Jr
Format: Article
Language:English
Published: AboutScience Srl 2009-01-01
Series:Drug Target Insights
Subjects:
individualized cancer chemotherapy
tumor targeting
bioreductive agents
NQO1
benzoquinone mustard
Online Access:http://www.la-press.com/a-model-for-nadphquinoneoxidoreductase-1-nqo1-targeted-individualized--a1276

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http://www.la-press.com/a-model-for-nadphquinoneoxidoreductase-1-nqo1-targeted-individualized--a1276

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