SAAMBE: Webserver to Predict the Charge of Binding Free Energy Caused by Amino Acids Mutations

SAAMBE: Webserver to Predict the Charge of Binding Free Energy Caused by Amino Acids Mutations

Predicting the effect of amino acid substitutions on protein–protein affinity (typically evaluated via the change of protein binding free energy) is important for both understanding the disease-causing mechanism of missense mutations and guiding protein engineering. In addition, researchers are also...

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Bibliographic Details
Main Authors: Marharyta Petukh, Luogeng Dai, Emil Alexov
Format: Article
Language:English
Published: MDPI AG 2016-04-01
Series:International Journal of Molecular Sciences
Subjects:
missense mutations
energy calculation
binding free energy
MM/PBSA method
Online Access:http://www.mdpi.com/1422-0067/17/4/547

Internet

http://www.mdpi.com/1422-0067/17/4/547

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