Reaction of diphenyl diselenide with hydrogen peroxide and inhibition of delta-aminolevulinate dehydratase from rat liver and cucumber leaves

The interaction of the product of H2O2 and (PhSe)2 with delta-aminolevulinate dehydratase (delta-ALA-D) from mammals and plants was investigated. (PhSe)2 inhibited rat hepatic delta-ALA-D with an IC50 of 10 µM but not the enzyme from cucumber leaves. The reaction of (PhSe)2 with H2O2 for 1 h increas...

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Bibliographic Details
Main Authors: M. Farina, N.B.V. Barbosa, C.W. Nogueira, V. Folmer, G. Zeni, L.H. Andrade, A. L. Braga, J.B.T. Rocha
Format: Article
Language:English
Published: Associação Brasileira de Divulgação Científica 2002-06-01
Series:Brazilian Journal of Medical and Biological Research
Subjects:
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2002000600001