The deubiquitylating enzyme USP15 regulates homologous recombination repair and cancer cell response to PARP inhibitors

The deubiquitylating enzyme USP15 regulates homologous recombination repair and cancer cell response to PARP inhibitors

Deubiquitinases have been shown to be involved in double strand break repair pathways. Here the authors reveal that USP15 deybiquitinase plays a role in homologues recombination repair by targeting BARD1 and affecting cells response to PARP inhibitors.

Bibliographic Details
Main Authors: Yihan Peng, Qingchao Liao, Wei Tan, Changmin Peng, Zhaohua Hu, Yali Chen, Zhuqing Li, Jing Li, Bei Zhen, Wenge Zhu, Xiangpan Li, Yi Yao, Qibin Song, Chengsheng Liu, Xiangdong Qi, Fuchu He, Huadong Pei
Format: Article
Language:English
Published: Nature Publishing Group 2019-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-09232-8

Internet

https://doi.org/10.1038/s41467-019-09232-8

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