Inhibition of glycine transporter-1 in the dorsal vagal complex improves metabolic homeostasis in diabetes and obesity

Glycine sensing in the dorsal vagal complex (DVC) regulates hepatic glucose production in rodents. Here the authors show that pharmacological and molecular inhibition of glycine reuptake in the DVC potentiates NMDA receptors, and improves metabolic homeostasis in animal models of obesity and diabete...

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Main Authors:	Jessica T. Y. Yue, Mona A. Abraham, Paige V. Bauer, Mary P. LaPierre, Peili Wang, Frank A. Duca, Beatrice M. Filippi, Owen Chan, Tony K. T. Lam
Format:	Article
Language:	English
Published:	Nature Publishing Group 2016-11-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/ncomms13501

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spelling	doaj-39518d1b32d94bf387969a5e946ba9b72021-05-11T11:04:34ZengNature Publishing GroupNature Communications2041-17232016-11-017111110.1038/ncomms13501Inhibition of glycine transporter-1 in the dorsal vagal complex improves metabolic homeostasis in diabetes and obesityJessica T. Y. Yue0Mona A. Abraham1Paige V. Bauer2Mary P. LaPierre3Peili Wang4Frank A. Duca5Beatrice M. Filippi6Owen Chan7Tony K. T. Lam8Toronto General Hospital Research Institute and Department of Medicine, UHNToronto General Hospital Research Institute and Department of Medicine, UHNToronto General Hospital Research Institute and Department of Medicine, UHNToronto General Hospital Research Institute and Department of Medicine, UHNDepartment of Internal Medicine, Section of Endocrinology, Yale University School of MedicineToronto General Hospital Research Institute and Department of Medicine, UHNToronto General Hospital Research Institute and Department of Medicine, UHNDepartment of Internal Medicine, Section of Endocrinology, Yale University School of MedicineToronto General Hospital Research Institute and Department of Medicine, UHNGlycine sensing in the dorsal vagal complex (DVC) regulates hepatic glucose production in rodents. Here the authors show that pharmacological and molecular inhibition of glycine reuptake in the DVC potentiates NMDA receptors, and improves metabolic homeostasis in animal models of obesity and diabetes.https://doi.org/10.1038/ncomms13501
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Jessica T. Y. Yue Mona A. Abraham Paige V. Bauer Mary P. LaPierre Peili Wang Frank A. Duca Beatrice M. Filippi Owen Chan Tony K. T. Lam
spellingShingle	Jessica T. Y. Yue Mona A. Abraham Paige V. Bauer Mary P. LaPierre Peili Wang Frank A. Duca Beatrice M. Filippi Owen Chan Tony K. T. Lam Inhibition of glycine transporter-1 in the dorsal vagal complex improves metabolic homeostasis in diabetes and obesity Nature Communications
author_facet	Jessica T. Y. Yue Mona A. Abraham Paige V. Bauer Mary P. LaPierre Peili Wang Frank A. Duca Beatrice M. Filippi Owen Chan Tony K. T. Lam
author_sort	Jessica T. Y. Yue
title	Inhibition of glycine transporter-1 in the dorsal vagal complex improves metabolic homeostasis in diabetes and obesity
title_short	Inhibition of glycine transporter-1 in the dorsal vagal complex improves metabolic homeostasis in diabetes and obesity
title_full	Inhibition of glycine transporter-1 in the dorsal vagal complex improves metabolic homeostasis in diabetes and obesity
title_fullStr	Inhibition of glycine transporter-1 in the dorsal vagal complex improves metabolic homeostasis in diabetes and obesity
title_full_unstemmed	Inhibition of glycine transporter-1 in the dorsal vagal complex improves metabolic homeostasis in diabetes and obesity
title_sort	inhibition of glycine transporter-1 in the dorsal vagal complex improves metabolic homeostasis in diabetes and obesity
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2016-11-01
description	Glycine sensing in the dorsal vagal complex (DVC) regulates hepatic glucose production in rodents. Here the authors show that pharmacological and molecular inhibition of glycine reuptake in the DVC potentiates NMDA receptors, and improves metabolic homeostasis in animal models of obesity and diabetes.
url	https://doi.org/10.1038/ncomms13501
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Inhibition of glycine transporter-1 in the dorsal vagal complex improves metabolic homeostasis in diabetes and obesity

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