Inhibition of glycine transporter-1 in the dorsal vagal complex improves metabolic homeostasis in diabetes and obesity

Inhibition of glycine transporter-1 in the dorsal vagal complex improves metabolic homeostasis in diabetes and obesity

Glycine sensing in the dorsal vagal complex (DVC) regulates hepatic glucose production in rodents. Here the authors show that pharmacological and molecular inhibition of glycine reuptake in the DVC potentiates NMDA receptors, and improves metabolic homeostasis in animal models of obesity and diabete...

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Bibliographic Details
Main Authors: Jessica T. Y. Yue, Mona A. Abraham, Paige V. Bauer, Mary P. LaPierre, Peili Wang, Frank A. Duca, Beatrice M. Filippi, Owen Chan, Tony K. T. Lam
Format: Article
Language:English
Published: Nature Publishing Group 2016-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms13501

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https://doi.org/10.1038/ncomms13501

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