Propylthiouracil, Perchlorate, and Thyroid-Stimulating Hormone Modulate High Concentrations of Iodide Instigated Mitochondrial Superoxide Production in the Thyroids of Metallothionein I/II Knockout Mice

Propylthiouracil, Perchlorate, and Thyroid-Stimulating Hormone Modulate High Concentrations of Iodide Instigated Mitochondrial Superoxide Production in the Thyroids of Metallothionein I/II Knockout Mice

BackgroundIncreased oxidative stress has been suggested as one of the underlying mechanisms in iodide excess-induced thyroid disease. Metallothioneins (MTs) are regarded as scavengers of reactive oxygen species (ROS) in oxidative stress. Our aim is to investigate the effects of propylthiouracil (PTU...

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Bibliographic Details
Main Authors: Qi Duan, Tingting Wang, Na Zhang, Vern Perera, Xue Liang, Iruni Roshanie Abeysekera, Xiaomei Yao
Format: Article
Language:English
Published: Academya Publishing Co. 2016-03-01
Series:Endocrinology and Metabolism
Subjects:
Propylthiouracil
Perchlorate
Thyrotropin
Metallothionein I/II knockout
Iodides
Online Access:http://e-enm.org/Synapse/Data/PDFData/2008ENM/enm-31-174.pdf

Internet

http://e-enm.org/Synapse/Data/PDFData/2008ENM/enm-31-174.pdf

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