Restoration of NK Cell Cytotoxic Function With Elotuzumab and Daratumumab Promotes Elimination of Circulating Plasma Cells in Patients With SLE

Restoration of NK Cell Cytotoxic Function With Elotuzumab and Daratumumab Promotes Elimination of Circulating Plasma Cells in Patients With SLE

Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease characterized by multiple cellular and molecular dysfunctions of the innate and adaptive immunity. Cytotoxic function of NK cells is compromised in patients with SLE. Herein, we characterized the phenotypic alterations of SLE NK...

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Bibliographic Details
Main Authors: Morgane Humbel, Florence Bellanger, Natalia Fluder, Alice Horisberger, Madeleine Suffiotti, Craig Fenwick, Camillo Ribi, Denis Comte
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Immunology
Subjects:
systemic lupus erythematosus (SLE)
SLAMF
CD38
elotuzumab
daratumumab
NK cells
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.645478/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.645478/full

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