Exome-wide age-of-onset analysis reveals exonic variants in ERN1 and SPPL2C associated with Alzheimer’s disease

Exome-wide age-of-onset analysis reveals exonic variants in ERN1 and SPPL2C associated with Alzheimer’s disease

Abstract Despite recent discoveries in genome-wide association studies (GWAS) of genomic variants associated with Alzheimer’s disease (AD), its underlying biological mechanisms are still elusive. The discovery of novel AD-associated genetic variants, particularly in coding regions and from APOE ε4 n...

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Bibliographic Details
Main Authors: Liang He, Yury Loika, Yongjin Park, Genotype Tissue Expression (GTEx) consortium, David A. Bennett, Manolis Kellis, Alexander M. Kulminski, for the Alzheimer’s Disease Neuroimaging Initiative
Format: Article
Language:English
Published: Nature Publishing Group 2021-02-01
Series:Translational Psychiatry
Online Access:https://doi.org/10.1038/s41398-021-01263-4

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https://doi.org/10.1038/s41398-021-01263-4

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