Rapid generation of gene-targeted EPS-derived mouse models through tetraploid complementation

Rapid generation of gene-targeted EPS-derived mouse models through tetraploid complementation

Abstract One major strategy to generate genetically modified mouse models is gene targeting in mouse embryonic stem (ES) cells, which is used to produce gene-targeted mice for wide applications in biomedicine. However, a major bottleneck in this approach is that the robustness of germline transmissi...

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Bibliographic Details
Main Authors: Haibo Li, Chaoran Zhao, Jun Xu, Yaxing Xu, Chunmei Cheng, Yinan Liu, Ting Wang, Yaqin Du, Liangfu Xie, Jingru Zhao, Yanchuang Han, Xiaobao Wang, Yun Bai, Hongkui Deng
Format: Article
Language:English
Published: SpringerOpen 2018-06-01
Series:Protein & Cell
Subjects:
tetraploid complementation
EPS
mouse model
CRISPR/Cas9
Online Access:http://link.springer.com/article/10.1007/s13238-018-0556-1

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http://link.springer.com/article/10.1007/s13238-018-0556-1

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