Two forms of CX3CL1 display differential activity and rescue cognitive deficits in CX3CL1 knockout mice

Two forms of CX3CL1 display differential activity and rescue cognitive deficits in CX3CL1 knockout mice

Abstract Background Fractalkine (CX3CL1; FKN) is a chemokine expressed by neurons that mediates communication between neurons and microglia. By regulating microglial activity, CX3CL1 can mitigate the damaging effects of chronic microglial inflammation within the brain, a state that plays a major rol...

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Bibliographic Details
Main Authors: Aimee N. Winter, Meena S. Subbarayan, Bethany Grimmig, Jason A. Weesner, Lauren Moss, Melinda Peters, Edwin Weeber, Kevin Nash, Paula C. Bickford
Format: Article
Language:English
Published: BMC 2020-05-01
Series:Journal of Neuroinflammation
Subjects:
Fractalkine
CX3CL1
Neuroinflammation
Microglia
Aging
Neurodegeneration
Online Access:http://link.springer.com/article/10.1186/s12974-020-01828-y

Internet

http://link.springer.com/article/10.1186/s12974-020-01828-y

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