Exogenous Pancreatic Kallikrein Improves Diabetic Cardiomyopathy in Streptozotocin-Induced Diabetes

Exogenous Pancreatic Kallikrein Improves Diabetic Cardiomyopathy in Streptozotocin-Induced Diabetes

Aims: To evaluate the protective effects of exogenous pancreatic kallikrein (PKK) treatment on diabetic cardiomyopathy (DCM) and explore the underlying mechanisms.Methods and Results: Streptozotocin (STZ)-induced diabetic rats, a type 1 diabetic model, were treated with either PKK or saline for 12 w...

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Bibliographic Details
Main Authors: Meng Wu, Yeping Yang, Meng Wang, Fangfang Zeng, Qin Li, Wenjuan Liu, Shizhe Guo, Min He, Yi Wang, Jie Huang, Linuo Zhou, Yiming Li, Ji Hu, Wei Gong, Zhaoyun Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-08-01
Series:Frontiers in Pharmacology
Subjects:
pancreatic kallikrein
diabetic cardiomyopathy
kallikrein-kinin system
fibrosis
inflammation
oxidative stress
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2018.00855/full

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https://www.frontiersin.org/article/10.3389/fphar.2018.00855/full

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