Postcoital bioavailability and antiviral activity of 0.5% PRO 2000 gel: implications for future microbicide clinical trials.

Postcoital bioavailability and antiviral activity of 0.5% PRO 2000 gel: implications for future microbicide clinical trials.

The pharmacokinetics and pharmacodynamics of vaginal microbicides are typically assessed among sexually abstinent women. However, the physical act of sex may modulate gel distribution, and preclinical studies demonstrate seminal plasma interferes with the antiviral activity of several microbicides....

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Bibliographic Details
Main Authors: Marla J Keller, Pedro M M Mesquita, N Merna Torres, Sylvia Cho, Gail Shust, Rebecca P Madan, Hillel W Cohen, Julie Petrie, Tara Ford, Lydia Soto-Torres, Albert T Profy, Betsy C Herold
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2809740?pdf=render

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http://europepmc.org/articles/PMC2809740?pdf=render

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