Dinucleosome specificity and allosteric switch of the ISW1a ATP-dependent chromatin remodeler in transcription regulation

Dinucleosome specificity and allosteric switch of the ISW1a ATP-dependent chromatin remodeler in transcription regulation

Here the authors show that the preference of yeast chromatin remodeler ISW1a for dinucleosomes hinges on conformational changes that occur in the transition from binding mononucleosomes to dinucleosomes. These changes are critical for ISW1a organizing chromatin at promoters and regulating transcript...

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Bibliographic Details
Main Authors: Saurabh K. Bhardwaj, Solomon G. Hailu, Lola Olufemi, Sandipan Brahma, Soumyadipta Kundu, Swetansu K. Hota, Jim Persinger, Blaine Bartholomew
Format: Article
Language:English
Published: Nature Publishing Group 2020-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-19700-1

Internet

https://doi.org/10.1038/s41467-020-19700-1

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