Caspase-11-dependent pyroptosis of lung epithelial cells protects from melioidosis while caspase-1 mediates macrophage pyroptosis and production of IL-18.

Caspase-11-dependent pyroptosis of lung epithelial cells protects from melioidosis while caspase-1 mediates macrophage pyroptosis and production of IL-18.

Infection with Burkholderia pseudomallei or B. thailandensis triggers activation of the NLRP3 and NLRC4 inflammasomes leading to release of IL-1β and IL-18 and death of infected macrophages by pyroptosis, respectively. The non-canonical inflammasome composed of caspase-11 is also activated by these...

Full description

Bibliographic Details
Main Authors: Jinyong Wang, Manoranjan Sahoo, Louis Lantier, Jonathan Warawa, Hector Cordero, Kelly Deobald, Fabio Re
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-05-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC5988316?pdf=render

Internet

http://europepmc.org/articles/PMC5988316?pdf=render

Similar Items