Population structuring of multi-copy, antigen-encoding genes in Plasmodium falciparum

Population structuring of multi-copy, antigen-encoding genes in Plasmodium falciparum

The coexistence of multiple independently circulating strains in pathogen populations that undergo sexual recombination is a central question of epidemiology with profound implications for control. An agent-based model is developed that extends earlier ‘strain theory’ by addressing the var gene fami...

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Bibliographic Details
Main Authors: Yael Artzy-Randrup, Mary M Rorick, Karen Day, Donald Chen, Andrew P Dobson, Mercedes Pascual
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2012-12-01
Series:eLife
Subjects:
parasite population structure
epidemiological dynamic
antigenic diversity
immune selection
Plasmodium falciparum
var multi-gene family
Online Access:https://elifesciences.org/articles/00093

Internet

https://elifesciences.org/articles/00093

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