Heterogeneous DNA Methylation Patterns in the GSTP1 Promoter Lead to Discordant Results between Assay Technologies and Impede Its Implementation as Epigenetic Biomarkers in Breast Cancer

Heterogeneous DNA Methylation Patterns in the GSTP1 Promoter Lead to Discordant Results between Assay Technologies and Impede Its Implementation as Epigenetic Biomarkers in Breast Cancer

Altered DNA methylation patterns are found in many diseases, particularly in cancer, where the analysis of DNA methylation holds the promise to provide diagnostic, prognostic and predictive information of great clinical value. Methylation of the promoter-associated CpG island of GSTP1 occurs in many...

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Bibliographic Details
Main Authors: Grethe I. Grenaker Alnaes, Jo Anders Ronneberg, Vessela N. Kristensen, Jörg Tost
Format: Article
Language:English
Published: MDPI AG 2015-09-01
Series:Genes
Subjects:
DNA methylation
breast cancer
GSTP1
biomarker
heterogeneity
method
MethyLight
MSP
pyrosequencing
mass spectrometry
Online Access:http://www.mdpi.com/2073-4425/6/3/878

Internet

http://www.mdpi.com/2073-4425/6/3/878

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