A feasibility study of controlled human infection with Streptococcus pneumoniae in Malawi

A feasibility study of controlled human infection with Streptococcus pneumoniae in Malawi

Background: Persistent carriage of pneumococcal vaccine serotypes has occurred after introduction of PCV13 vaccination in Africa but the mechanisms are unclear. We tested the feasibility of using a human pneumococcal challenge model in Malawi to understand immune correlates of protection against car...

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Bibliographic Details
Main Authors: Ben Morton, Sarah Burr, Tarsizio Chikaonda, Edna Nsomba, Lucinda Manda-Taylor, Marc Y.R. Henrion, Ndaziona Peter Banda, Jamie Rylance, Daniela M. Ferreira, Kondwani Jambo, Stephen B. Gordon
Format: Article
Language:English
Published: Elsevier 2021-10-01
Series:EBioMedicine
Subjects:
Streptococcus pneumoniae
Human infection model
Nasal
Mucosal inflammation
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396421003728

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http://www.sciencedirect.com/science/article/pii/S2352396421003728

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