Metastasis in context: modeling the tumor microenvironment with cancer-on-a-chip approaches

Most cancer deaths are not caused by the primary tumor, but by secondary tumors formed through metastasis, a complex and poorly understood process. Cues from the tumor microenvironment, such as the biochemical composition, cellular population, extracellular matrix, and tissue (fluid) mechanics, have...

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Bibliographic Details
Main Authors: Jelle J. F. Sleeboom, Hossein Eslami Amirabadi, Poornima Nair, Cecilia M. Sahlgren, Jaap M. J. den Toonder
Format: Article
Language:English
Published: The Company of Biologists 2018-03-01
Series:Disease Models & Mechanisms
Subjects:
Online Access:http://dmm.biologists.org/content/11/3/dmm033100