Design, synthesis and pharmacological evaluation of 4-(3-chloro-4-(3-cyclopropylthioureido)-2-fluorophenoxy)-7-methoxyquinoline-6-carboxamide (WXFL-152): a novel triple angiokinase inhibitor for cancer therapy

Design, synthesis and pharmacological evaluation of 4-(3-chloro-4-(3-cyclopropylthioureido)-2-fluorophenoxy)-7-methoxyquinoline-6-carboxamide (WXFL-152): a novel triple angiokinase inhibitor for cancer therapy

Angiokinases, such as vascular endothelial-, fibroblast- and platelet-derived growth factor receptors (VEGFRs, FGFRs and PDGFRs) play crucial roles in tumor angiogenesis. Anti-angiogenesis therapy using multi-angiokinase inhibitor has achieved great success in recent years. In this study, we present...

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Bibliographic Details
Main Authors: Yuqin Yao, Zhuowei Liu, Manyu Zhao, Zhengxia Chen, Peng Li, Yang Zhang, Yuxi Wang, Chengjian Zhao, Chaofeng Long, Xiaoxin Chen, Jinliang Yang
Format: Article
Language:English
Published: Elsevier 2020-08-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Drug synthesis
Tumor
Anti-angiogenesis therapy
Multi-angiokinase inhibitor
Pharmacokinetic
Online Access:http://www.sciencedirect.com/science/article/pii/S221138352030544X

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http://www.sciencedirect.com/science/article/pii/S221138352030544X

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