Cryo-EM structure of Saccharomyces cerevisiae target of rapamycin complex 2

Cryo-EM structure of Saccharomyces cerevisiae target of rapamycin complex 2

Target of rapamycin (TOR) kinase operates within two distinct multiprotein complexes named TORC1 and TORC2. Here the authors report a cryo-EM structure of TORC2, establish its subunit organization, providing a rationale for TORC2’s rapamycin insensitivity and the mutually exclusive inclusion of Avo3...

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Bibliographic Details
Main Authors: Manikandan Karuppasamy, Beata Kusmider, Taiana M. Oliveira, Christl Gaubitz, Manoel Prouteau, Robbie Loewith, Christiane Schaffitzel
Format: Article
Language:English
Published: Nature Publishing Group 2017-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-01862-0

Internet

https://doi.org/10.1038/s41467-017-01862-0

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