Epigenetic Regulation of Genomic Stability by Vitamin C

Epigenetic Regulation of Genomic Stability by Vitamin C

DNA methylation plays an important role in the maintenance of genomic stability. Ten-eleven translocation proteins (TETs) are a family of iron (Fe2+) and α-KG -dependent dioxygenases that regulate DNA methylation levels by oxidizing 5-methylcystosine (5mC) to generate 5-hydroxymethylcytosine (5hmC),...

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Bibliographic Details
Main Authors: John P. Brabson, Tiffany Leesang, Sofia Mohammad, Luisa Cimmino
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Genetics
Subjects:
DNA methylation (5mC)
DNMT
5-hydroxymethylation (5hmC)
TET
genomic stability
vitamin C
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2021.675780/full

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https://www.frontiersin.org/articles/10.3389/fgene.2021.675780/full

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