Pharmacological Inhibition of O-GlcNAcase Does Not Increase Sensitivity of Glucocorticoid Receptor-Mediated Transrepression.

Pharmacological Inhibition of O-GlcNAcase Does Not Increase Sensitivity of Glucocorticoid Receptor-Mediated Transrepression.

Glucocorticoid signaling regulates target genes by multiple mechanisms, including the repression of transcriptional activities of nuclear factor κ-light-chain-enhancer of activated B cells (NF-κB) though direct protein-protein interactions and subsequent O-GlcNAcylation of RNA polymerase II (pol II)...

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Bibliographic Details
Main Authors: Peter J Stivers, Lauren Harmonay, Alexandra Hicks, Huseyin Mehmet, Melody Morris, Gain M Robinson, Peter R Strack, Mary J Savage, Dennis M Zaller, Izabela Zwierzynski, Philip E Brandish
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4682863?pdf=render

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http://europepmc.org/articles/PMC4682863?pdf=render

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