Novel immunomodulatory drugs and neo-substrates

Abstract Thalidomide, lenalidomide and pomalidomide are immunomodulatory drugs (IMiDs) effective in the treatment of multiple myeloma, myelodysplastic syndrome (MDS) with deletion of chromosome 5q and other hematological malignancies. Recent studies showed that IMiDs bind to CRBN, a substrate recept...

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Bibliographic Details
Main Authors: Shaobing Gao, Shichao Wang, Yongping Song
Format: Article
Language:English
Published: BMC 2020-01-01
Series:Biomarker Research
Subjects:
Online Access:https://doi.org/10.1186/s40364-020-0182-y