ERK Phosphorylation Regulates the Aml1/Runx1 Splice Variants and the TRP Channels Expression during the Differentiation of Glioma Stem Cell Lines

ERK Phosphorylation Regulates the Aml1/Runx1 Splice Variants and the TRP Channels Expression during the Differentiation of Glioma Stem Cell Lines

The identification of cancer stem cells in brain tumors paved the way for new therapeutic approaches. Recently, a role for the transcriptional factor Runx1/Aml1 and the downstream ion channel genes in brain cancer development and progression has been suggested. This study aimed to explore the expres...

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Bibliographic Details
Main Authors: Giorgio Santoni, Massimo Nabissi, Consuelo Amantini, Matteo Santoni, Lucia Ricci-Vitiani, Roberto Pallini, Federica Maggi, Maria Beatrice Morelli
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Cells
Subjects:
glioma stem cells
neural differentiation
Aml1 splice variants
ERK
TRP channel
TRPV1
Online Access:https://www.mdpi.com/2073-4409/10/8/2052

Internet

https://www.mdpi.com/2073-4409/10/8/2052

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