Search of protein kinase CK2 inhibitors based on purine-2,6-diones derivatives

Search of protein kinase CK2 inhibitors based on purine-2,6-diones derivatives

This work is aimed to the search of protein kinase CK2 inhibitors among the purine-2,6-dione derivatives by molecular docking and biochemical tests. It was found that the most active compound 8-[2-[(3-methoxyphenyl)methylidene]hydrazine-1-yl]-3-methyl-7-(3-phenoxypropyl)-2,3,6,7-tetrahydro-1H-purine...

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Bibliographic Details
Main Authors: M. V. Protopopov, O. V. Ostrynska, D. H. Ivanchenko, S. A. Starosyla, V. G. Bdzhola, M. I. Romanenko, S. M. Yarmoluk
Format: Article
Language:English
Published: National Academy of Sciences of Ukraine and Palladin Institute of Biochemistry of the National Academy of Sciences of Ukraine. 2017-10-01
Series:Ukrainian Biochemical Journal
Subjects:
inhibitor
protein kinase CK2
purine-2_6-dione
virtual screening
xanthine
Online Access:http://ukrbiochemjournal.org/wp-content/uploads/2017/10/Protopopov_5-17.pdf

Internet

http://ukrbiochemjournal.org/wp-content/uploads/2017/10/Protopopov_5-17.pdf

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