Enhanced inflammasome activation and reduced sphingosine-1 phosphate S1P signalling in a respiratory mucoobstructive disease model

Enhanced inflammasome activation and reduced sphingosine-1 phosphate S1P signalling in a respiratory mucoobstructive disease model

Abstract Background Inflammasomes and sphingosine-1-phosphate (S1P) signalling are increasingly subject to intensive research in human diseases. We hypothesize that in respiratory muco-obstructive diseases, mucus obstruction enhances NLRP3 inflammasome activation and dysregulated S1P signalling. Met...

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Bibliographic Details
Main Authors: Hai B. Tran, Matthew G. Macowan, Adrian Abdo, Martin Donnelley, David Parsons, Sandra Hodge
Format: Article
Language:English
Published: BMC 2020-04-01
Series:Journal of Inflammation
Subjects:
Inflammasome
Sphingosine-1 phosphate
Respiratory muco-obstructive diseases
Cystic fibrosis
Mouse model
Online Access:http://link.springer.com/article/10.1186/s12950-020-00248-2

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http://link.springer.com/article/10.1186/s12950-020-00248-2

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