Meningioma cells express primary cilia but do not transduce ciliary Hedgehog signals

Meningioma cells express primary cilia but do not transduce ciliary Hedgehog signals

Abstract Meningiomas are the most common primary intracranial tumors, but treatment options for meningioma patients are limited due to incomplete understanding of tumor biology. A small percentage of meningiomas harbor somatic variants in the Hedgehog pathway, a conserved gene expression program tha...

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Bibliographic Details
Main Authors: Sarah Findakly, Abrar Choudhury, Vikas Daggubati, Melike Pekmezci, Ursula E. Lang, David R. Raleigh
Format: Article
Language:English
Published: BMC 2020-07-01
Series:Acta Neuropathologica Communications
Subjects:
Cilia
Hedgehog
Meningioma
Primary cilium
Smoothened
Vismodegib
Online Access:http://link.springer.com/article/10.1186/s40478-020-00994-7

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http://link.springer.com/article/10.1186/s40478-020-00994-7

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