Drp1 Promotes KRas-Driven Metabolic Changes to Drive Pancreatic Tumor Growth

Drp1 Promotes KRas-Driven Metabolic Changes to Drive Pancreatic Tumor Growth

Summary: Mitochondria undergo fission and fusion to maintain homeostasis, and tumors exhibit the dysregulation of mitochondrial dynamics. We recently demonstrated that ectopic HRasG12V promotes mitochondrial fragmentation and tumor growth through Erk phosphorylation of the mitochondrial fission GTPa...

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Bibliographic Details
Main Authors: Sarbajeet Nagdas, Jennifer A. Kashatus, Aldo Nascimento, Syed S. Hussain, Riley E. Trainor, Sarah R. Pollock, Sara J. Adair, Alex D. Michaels, Hiromi Sesaki, Edward B. Stelow, Todd W. Bauer, David F. Kashatus
Format: Article
Language:English
Published: Elsevier 2019-08-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124719309283

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http://www.sciencedirect.com/science/article/pii/S2211124719309283

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