Microbial Stimulation Reverses the Age-Related Decline in M Cells in Aged Mice

Summary: Aging has a profound effect on the immune system, termed immunosenescence, resulting in increased incidence and severity of infections and decreased efficacy of vaccinations. We previously showed that immunosurveillance in the intestine, achieved primarily through antigen sampling M cells i...

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Bibliographic Details
Main Authors: David S. Donaldson, Jolinda Pollock, Prerna Vohra, Mark P. Stevens, Neil A. Mabbott
Format: Article
Language:English
Published: Elsevier 2020-06-01
Series:iScience
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004220303321