Complementary Targeting of Rb Phosphorylation and Growth in Cervical Cancer Cell Cultures and a Xenograft Mouse Model by SHetA2 and Palbociclib

Complementary Targeting of Rb Phosphorylation and Growth in Cervical Cancer Cell Cultures and a Xenograft Mouse Model by SHetA2 and Palbociclib

Cervical cancer is caused by high-risk human papillomavirus (HPV) types and treated with conventional chemotherapy with surgery and/or radiation. HPV E6 and E7 proteins increase phosphorylation of retinoblastoma (Rb) by cyclin D1/cyclin dependent kinase (CDK)4/6 complexes. We hypothesized that cycli...

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Bibliographic Details
Main Authors: Amy L. Kennedy, Rajani Rai, Zitha Redempta Isingizwe, Yan Daniel Zhao, Stanley A. Lightfoot, Doris M. Benbrook
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:Cancers
Subjects:
cyclin D1
retinoblastoma
palbociblib
SHetA2
cervical cancer
Online Access:https://www.mdpi.com/2072-6694/12/5/1269

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https://www.mdpi.com/2072-6694/12/5/1269

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