Protective Role of the Nucleic Acid Sensor STING in Pulmonary Fibrosis

Protective Role of the Nucleic Acid Sensor STING in Pulmonary Fibrosis

Idiopathic pulmonary fibrosis (IPF) is the most common and severe type of interstitial lung disease for which current treatments display limited efficacy. IPF is largely driven by host-derived danger signals released upon recurrent local tissue damage. Here we explored the roles of self-DNA and stim...

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Bibliographic Details
Main Authors: Florence Savigny, Corinne Schricke, Norinne Lacerda-Queiroz, Mélanie Meda, Mégane Nascimento, Sarah Huot-Marchand, Felipe Da Gama Monteiro, Bernhard Ryffel, Aurélie Gombault, Marc Le Bert, Isabelle Couillin, Nicolas Riteau
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Immunology
Subjects:
idiopathic pulmonary fibrosis
STING
self-DNA recognition
mice
IL-28
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2020.588799/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2020.588799/full

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