New transgenic models of Parkinson's disease using genome editing technology

Introduction: Parkinson's disease (PD) is the second most common neurodegenerative disorder. It is characterised by selective loss of dopaminergic neurons in the substantia nigra pars compacta, which results in dopamine depletion, leading to a number of motor and non-motor symptoms. Development...

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Main Authors: J.A. Cota-Coronado, S. Sandoval-Ávila, Y.P. Gaytan-Dávila, N.F. Diaz, B. Vega-Ruiz, E. Padilla-Camberos, N.E. Díaz-Martínez
Format: Article
Language:English
Published: Elsevier España 2020-09-01
Series:Neurología (English Edition)
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Online Access:http://www.sciencedirect.com/science/article/pii/S2173580819300768