Controlling Depth of Cellular Quiescence by an Rb-E2F Network Switch

Controlling Depth of Cellular Quiescence by an Rb-E2F Network Switch

Quiescence is a non-proliferative cellular state that is critical to tissue repair and regeneration. Although often described as the G0 phase, quiescence is not a single homogeneous state. As cells remain quiescent for longer durations, they move progressively deeper and display a reduced sensitivit...

Full description

Bibliographic Details
Main Authors: Jungeun Sarah Kwon, Nicholas J. Everetts, Xia Wang, Weikang Wang, Kimiko Della Croce, Jianhua Xing, Guang Yao
Format: Article
Language:English
Published: Elsevier 2017-09-01
Series:Cell Reports
Subjects:
cellular quiescence
quiescence depth
quiescence heterogeneity
cell cycle entry
cell proliferation
cell growth
Rb-E2F pathway
bistable switch
model simulation
activation threshold
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717312688

Internet

http://www.sciencedirect.com/science/article/pii/S2211124717312688

Similar Items