Genome-Wide Identification of Host Genes Required for Toxicity of Bacterial Cytolethal Distending Toxin in a Yeast Model

Genome-Wide Identification of Host Genes Required for Toxicity of Bacterial Cytolethal Distending Toxin in a Yeast Model

BackgroundAggregatibacter actinomycetemcomitans, a periodontal pathogen, secretes a cytolethal distending toxin (AaCDT) that causes host cell cycle arrest and cell death. Although CDT could be an important virulence factor, it is unclear how it enters the nucleus to exert its cytotoxicity.ObjectiveT...

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Bibliographic Details
Main Authors: Siriyod Denmongkholchai, Prashant Katare, Sarocha Choochuay, Panida Thanyasrisung, Keiko Tsuruda, Motoyuki Sugai, Skorn Mongkolsuk, Oranart Matangkasombut
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-04-01
Series:Frontiers in Microbiology
Subjects:
Aggregatibacter actinomycetemcomitans
bacterial genotoxin
cytolethal distending toxin
cytotoxicity
host factors
Saccharomyces cerevisiae
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2019.00890/full

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https://www.frontiersin.org/article/10.3389/fmicb.2019.00890/full

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