Electrophysiological and Contractile Effects of Disopyramide in Patients With Obstructive Hypertrophic Cardiomyopathy

Electrophysiological and Contractile Effects of Disopyramide in Patients With Obstructive Hypertrophic Cardiomyopathy

Summary: Disopyramide is effective and safe in patients with obstructive hypertrophic cardiomyopathy. However, its cellular and molecular mechanisms of action are unknown. We tested disopyramide in cardiomyocytes from the septum of surgical myectomy patients: disopyramide inhibits multiple ion chann...

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Main Authors: Raffaele Coppini, MD, PhD, Cecilia Ferrantini, MD, PhD, Josè Manuel Pioner, PhD, Lorenzo Santini, MS, Zhinuo J. Wang, PhD, Chiara Palandri, MS, Marina Scardigli, PhD, Giulia Vitale, MS, Leonardo Sacconi, PhD, Pierluigi Stefàno, MD, Laura Flink, MD, Katherine Riedy, MD, Francesco Saverio Pavone, PhD, Elisabetta Cerbai, PhD, Corrado Poggesi, MD, Alessandro Mugelli, MD, Alfonso Bueno-Orovio, PhD, Iacopo Olivotto, MD, Mark V. Sherrid, MD
Format: Article
Language:English
Published: Elsevier 2019-11-01
Series:JACC: Basic to Translational Science
Online Access:http://www.sciencedirect.com/science/article/pii/S2452302X19301871

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http://www.sciencedirect.com/science/article/pii/S2452302X19301871

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