Effects of PCSK9 genetic variants on plasma LDL cholesterol levels and risk of premature myocardial infarction in the Italian population

Effects of PCSK9 genetic variants on plasma LDL cholesterol levels and risk of premature myocardial infarction in the Italian population

The R46L variant in the proprotein-convertase subtilisin-kexin type 9 (PCSK9) gene was associated with reduced levels of LDL and total cholesterol and with a lower risk of coronary artery disease. We investigated the association of R46L with myocardial infarction (MI) in 1,880 Italian patients with...

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Bibliographic Details
Main Authors: Ilaria Guella, Rosanna Asselta, Diego Ardissino, Pier Angelica Merlini, Flora Peyvandi, Sekar Kathiresan, Pier Mannuccio Mannucci, Marco Tubaro, Stefano Duga
Format: Article
Language:English
Published: Elsevier 2010-11-01
Series:Journal of Lipid Research
Subjects:
proprotein-convertase subtilisin-kexin type 9 genetic variants
low density lipoprotein
association study
Online Access:http://www.sciencedirect.com/science/article/pii/S002222752040968X

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http://www.sciencedirect.com/science/article/pii/S002222752040968X

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