HMGB1 Aggravates Pressure Overload-Induced Left Ventricular Dysfunction by Promoting Myocardial Fibrosis

Aim. Fibrosis had important effects on pressure overload-induced left ventricular (LV) dysfunction. High-mobility group box 1 (HMGB1), which was closely associated with fibrosis, was involved in the pressure overload-induced cardiac injury. This study determines the role of HMGB1 in LV dysfunction u...

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Bibliographic Details
Main Authors: Lei Zhang, Ying Yu, Peng Yu, Jian Wu, Aijun Sun, Yunzeng Zou, Yangang Su, Hong Jiang, Junbo Ge
Format: Article
Language:English
Published: Hindawi Limited 2020-01-01
Series:International Journal of Hypertension
Online Access:http://dx.doi.org/10.1155/2020/7270351