A Pro-Tumorigenic Effect of Heparanase 2 (Hpa2) in Thyroid Carcinoma Involves Its Localization to the Nuclear Membrane

A Pro-Tumorigenic Effect of Heparanase 2 (Hpa2) in Thyroid Carcinoma Involves Its Localization to the Nuclear Membrane

Activity of the endo-beta-glucuronidase heparanase, capable of cleaving heparan sulfate (HS), is most often elevated in many types of tumors, associating with increased tumor metastasis and decreased patients’ survival. Heparanase is therefore considered to be a valid drug target, and heparanase inh...

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Bibliographic Details
Main Authors: Itai Margulis, Inna Naroditsky, Miriam Gross-Cohen, Neta Ilan, Israel Vlodavsky, Ilana Doweck
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Oncology
Subjects:
thyroid carcinoma
heparanase 2
immunostaining
localization
nuclear membrane
metastasis
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.645524/full

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https://www.frontiersin.org/articles/10.3389/fonc.2021.645524/full

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