Silane Reduction of 5-Hydroxy-6-methyl-pyridine-3,4-dicarboxylic Acid Diethyl Ester: Synthesis of Vitamin B6

Silane Reduction of 5-Hydroxy-6-methyl-pyridine-3,4-dicarboxylic Acid Diethyl Ester: Synthesis of Vitamin B6

Alternative methods for the synthesis of pyridoxine have been investigated. The key intermediate, 5-hydroxy-6-methyl-pyridine-3,4-dicarboxylic acid diethyl ester (5), was reduced with either a silane monomer (MeSiH(OEt)2) or a polysiloxane (polymethylhydrosiloxane, PMHS) to afford crude pyridoxine....

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Bibliographic Details
Main Authors: Andrew G. Gum, Yves René Dumond
Format: Article
Language:English
Published: MDPI AG 2003-12-01
Series:Molecules
Subjects:
Polymethylhydrosiloxane (PMHS)
silanes
ester reduction
pyridoxine
vitamin B6
Online Access:http://www.mdpi.com/1420-3049/8/12/873/

Internet

http://www.mdpi.com/1420-3049/8/12/873/

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