The tight junction protein TJP1 regulates the feeding-modulated hepatic circadian clock

The circadian clock regulates rhythms of physiology and metabolism in response to environmental cues such as food intake. Here, the authors show that tight junction protein 1 (TJP1) interacts with period 1 and modulates its nuclear translocation in a mTOR-dependent manner.

Bibliographic Details
Main Authors: Yi Liu, Yuanyuan Zhang, Tong Li, Jinbo Han, Yiguo Wang
Format: Article
Language:English
Published: Nature Publishing Group 2020-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-14470-2
Description
Summary:The circadian clock regulates rhythms of physiology and metabolism in response to environmental cues such as food intake. Here, the authors show that tight junction protein 1 (TJP1) interacts with period 1 and modulates its nuclear translocation in a mTOR-dependent manner.
ISSN:2041-1723