Conjugation with Acridines Turns Nuclear Localization Sequence into Highly Active Antimicrobial Peptide

Conjugation with Acridines Turns Nuclear Localization Sequence into Highly Active Antimicrobial Peptide

The emergence of multidrug-resistant bacteria creates an urgent need for alternative antibiotics with new mechanisms of action. In this study, we synthesized a novel type of antimicrobial agent, Acr3-NLS, by conjugating hydrophobic acridines to the N-terminus of a nuclear localization sequence (NLS)...

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Bibliographic Details
Main Authors: Wei Zhang, Xiaoli Yang, Jingjing Song, Xin Zheng, Jianbo Chen, Panpan Ma, Bangzhi Zhang, Rui Wang
Format: Article
Language:English
Published: Elsevier 2015-12-01
Series:Engineering
Subjects:
acridine
nuclear localization sequence
conjugate
antimicrobial activity
mechanism of action
Online Access:http://www.sciencedirect.com/science/article/pii/S2095809916300303

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http://www.sciencedirect.com/science/article/pii/S2095809916300303

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