Tacrolimus Reverses UVB Irradiation-Induced Epidermal Langerhans Cell Reduction by Inhibiting TNF-α Secretion in Keratinocytes via Regulation of NF-κB/p65

Tacrolimus Reverses UVB Irradiation-Induced Epidermal Langerhans Cell Reduction by Inhibiting TNF-α Secretion in Keratinocytes via Regulation of NF-κB/p65

Background: Topical calcineurin inhibitors including tacrolimus and pimecrolimus are used in the treatment of many inflammatory skin diseases mainly via blocking T-cell proliferation. Our previous studies found that pimecrolimus 1% cream could reverse high-dose ultraviolet B (UVB) irradiation-induce...

Full description

Bibliographic Details
Main Authors: JiaLi Xu, YaDong Feng, GuoXin Song, QiXing Gong, Li Yin, YingYing Hu, Dan Luo, ZhiQiang Yin
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-02-01
Series:Frontiers in Pharmacology
Subjects:
tacrolimus
UVB
Langerhans cells
TNF-α
NF-κB
Online Access:http://journal.frontiersin.org/article/10.3389/fphar.2018.00067/full

Internet

http://journal.frontiersin.org/article/10.3389/fphar.2018.00067/full

Similar Items