Clinical features of male patients with alcoholic liver cirrhosis or hepatitis B cirrhosis complicated by abnormal glucose metabolism

ObjectiveTo investigate the clinical features of male patients with alcoholic liver cirrhosis (ALC) or hepatitis B cirrhosis (HBC) complicated by abnormal glucose metabolism. MethodsA total of 287 patients with liver cirrhosis who were admitted to Guangzhou Panyu Central Hospital from January 2008 t...

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Bibliographic Details
Main Authors:	CHEN Qidan, WAN Yu
Format:	Article
Language:	zho
Published:	Editorial Department of Journal of Clinical Hepatology 2016-02-01
Series:	Linchuang Gandanbing Zazhi
Subjects:	74 had ALC and were all male including 54 with abnormal glucose metabolism; the other 213 had HBC including 97 with abnormal glucose metabolism (69 male patients and 28 female patients). A controlled study was performed for the clinical data of ALC and HBC patients with abnormal glucose metabolism to investigate the association of patients′ clinical manifestations with the indices for laboratory examination insulin resistance index incidence rate of abnormal glucose metabolism and Child-Pugh class. The t-test was applied for comparison of continuous data between groups the chi-square test was applied for comparison of categorical data between groups and the Spearman rank correlation was applied for correlation analysis. ResultsCompared with HBC patients ALC patients had significantly higher incidence rates of abnormal glucose metabolism (730% vs 32.4%) hepatogenous diabetes (35.1% vs 14.6%) fasting hypoglycemia (27.0% vs 10.3%) and impaired glucose tolerance (31.1% vs 14.1%) (χ2=4.371 3.274 4.784 and 1.633 all P＜0.05). The Spearman correlation analysis showed that in ALC and HBC patients the incidence rate of abnormal glucose metabolism was positively correlated with Child-Pugh class (rs=0.41 P＜005). Compared with the HBC patients with abnormal glucose metabolism the ALC patients with abnormal glucose metabolism had a significantly higher incidence rate of Child-Pugh class A (χ2=7.520 P=0.001) and a significantly lower incidence rate of Child-Pugh class C (χ2=6.542 P=0.003). There were significant differences in the incidence rates of dim complexion telangiectasia of the face spider angioma hepatomegaly hepatorenal syndrome malnutrition ascites jaundice hepatic encephalopathy spontaneous bacterial peritonitis and upper gastrointestinal bleeding between the ALC and HBC patients with abnormal glucose metabolism (χ2=3.785 2.651 1974 3.316 3.771 5.843 7.251 5.214 5.778 2.966 and 6.312 all P＜0.05). Compared with the HBC patients with abnormal glucose metabolism the ALC patients with abnormal glucose metabolism had significantly higher levels of aspartate aminotransferase and total bilirubin a significantly greater mean corpuscular volume a significantly higher level of gamma-glutamyl transpeptidase and a significantly lower level of albumin (t=4.775 7.887 5.143 6.124 and 5.210 all P＜0.05). There were significant differences in the fasting blood glucose level insulin level 2 hours after meal and insulin resistance index between the ALC and HBC patients with abnormal glucose metabolism (t=2.770 6.331 and 3.770 all P＜0.05). ConclusionThe male patients with ALC or HBC gradually develop abnormal glucose metabolism with the deterioration of liver function with individual etiology and features of liver cirrhosis and the manifestations of abnormal glucose metabolism are not obvious. Related examinations should be performed for these male patients with liver cirrhosis of various causes liver cirrhosis alcoholic hepatitis B glucose metabolism disorders
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Clinical features of male patients with alcoholic liver cirrhosis or hepatitis B cirrhosis complicated by abnormal glucose metabolism

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