p16INK4A and p14ARF Gene Promoter Hypermethylation as Prognostic Biomarker in Oral and Oropharyngeal Squamous Cell Carcinoma: A Review

Head and neck squamous cell carcinoma is a heterogeneous group of tumors with each subtype having a distinct histopathological and molecular profile. Most tumors share, to some extent, the same multistep carcinogenic pathways, which include a wide variety of genetic and epigenetic changes. Epigeneti...

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Bibliographic Details
Main Authors: A. Al-Kaabi, L. W. van Bockel, A. J. Pothen, S. M. Willems
Format: Article
Language:English
Published: Hindawi Limited 2014-01-01
Series:Disease Markers
Online Access:http://dx.doi.org/10.1155/2014/260549