Human Domain Antibodies to Conserved Epitopes on HER2 Potently Inhibit Growth of HER2-Overexpressing Human Breast Cancer Cells In Vitro

Human Domain Antibodies to Conserved Epitopes on HER2 Potently Inhibit Growth of HER2-Overexpressing Human Breast Cancer Cells In Vitro

The FDA approval of two anti-HER2 monoclonal antibodies, trastuzumab and pertuzumab, and an antibody-drug conjugate, trastuzumab emtansine, has transformed clinical practice for HER2-positive cancers. However, not all patients respond to therapy, and the majority of responders eventually develop res...

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Bibliographic Details
Main Authors: Hongqian Wang, Yanping Wang, Zuoxiang Xiao, Wei Li, Dimiter S. Dimitrov, Weizao Chen
Format: Article
Language:English
Published: MDPI AG 2019-03-01
Series:Antibodies
Subjects:
HER2
cancer
therapy
domain antibody
conserved epitope
Online Access:http://www.mdpi.com/2073-4468/8/1/25

Internet

http://www.mdpi.com/2073-4468/8/1/25

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