A Small-Molecule Screen for Enhanced Homing of Systemically Infused Cells

A Small-Molecule Screen for Enhanced Homing of Systemically Infused Cells

Poor homing of systemically infused cells to disease sites may limit the success of exogenous cell-based therapy. In this study, we screened 9,000 signal-transduction modulators to identify hits that increase mesenchymal stromal cell (MSC) surface expression of homing ligands that bind to intercellu...

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Bibliographic Details
Main Authors: Oren Levy, Luke J. Mortensen, Gerald Boquet, Zhixiang Tong, Christelle Perrault, Brigitte Benhamou, Jidong Zhang, Tara Stratton, Edward Han, Helia Safaee, Juliet Musabeyezu, Zijiang Yang, Marie-Christine Multon, Jonathan Rothblatt, Jean-Francois Deleuze, Charles P. Lin, Jeffrey M. Karp
Format: Article
Language:English
Published: Elsevier 2015-03-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124715000996

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http://www.sciencedirect.com/science/article/pii/S2211124715000996

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